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In addition, in the case of infants, children, adolescents, and pregnant women, nicotine can impair brain development, potentially leading to cognitive and behavioural issues

Subluxation of the large joints may occur Other features include - poor response to local anaesthetic and reduced awareness of joint position (proprioception) Most patients with EDS have a normal life expectancy, however, the vascular type (Ehlers-Danlos syndrome IV) is associated with major complications that arise following spontaneous rupture of large arteries, as well as the colon and gravid uterus Clinical Images Please refer to notes on image rights at bottom of the page with regards to individual image ownership

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It was the kind of painful gut punch that can destroy an aspiring comedians confidence