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Graphical Abstract Valproic acid induces placental toxicity in pregnant rats, while bioactive folates (5-MTHF and folinic acid) provide protective effects

The ML210 small molecule is likely to exert its inhibitory effect by covalently modifying the selenocysteine of GPX4 [162, 163]

Unlike with oral supplements, due to the breakdown by stomach and enzymes only portion of the medication are absorbed by the body, that weakens its potency and efficacy