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Once c-MET binds with HGF, it can mediate various downstream signaling molecules such as the MAPK family, JAK/STAT3, and PI3K/AKT, interacting with other ligand-receptor downstream pathways (Zhao et al., 2022)

A 2020 review concluded that overall, studies to date report that riboflavin has similar efficacy to valproate for migraine prophylaxis, but has a more tolerable side effect profile