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Clinical studies comparing the gut microbiota of HD gene expansion carriers with healthy controls have found a significant reduction in both the quantity and diversity of gut microbiota in HD carriers (Wasser et al., 2020)

Ann Neurol 2012

Choline is an essential nutrient that functions as a structural component of cell membranes, a methyl group donor in metabolic reactions, and a precursor for the neurotransmitter acetylcholine