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12 , e12476 (2020)

Mounting evidence indicates that gains in healthy life expectancy lag significantly behind total life expectancy, a disparity that is especially pronounced in the elderly population [6,7,8,9,10]

The studies controlled for BMI at baseline and updated diabetes diagnoses during follow-up

In addition, the classical metabolic drug metformin increases oocyte maturation rate and early embryonic developmental potential in aged mice cultured in an in vitro maturation system through a mechanism involving SIRT3-mediated deacetylation of SOD2, which mitigates mitochondrial damage [362]