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Mouse-model results should not be assumed to predict human outcomes at any dose or by any route

AuNPs are increasingly being explored as promising vehicles for therapeutic applications such as targeted cargo delivery and photothermal therapies (PTT) due to their unique physicochemical properties, tunable surface chemistry and their easy bio-conjugation 8,9,10,11,12,13

This reaction requires the release of a methyl group from CH3-H4folate to H4folate, the two main circulating forms of folic acid (vitamin B9) in pigs (Natsuhori et al., 1996)