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Front in Immunol

Nrf2-ARE pathway In vitiligo, inactive Nrf2 signaling is ineffective in protecting HEM from H 2 O 2 -induced OS damage and, therefore, rarely prevents melanocyte apoptosis by mediating its downstream antioxidant gene heme oxygenase-1 (HO-1) (120)

This dual mechanism, weight-mediated and insulin-mediated aromatase reduction, may explain why some endometriosis patients see improvements that seem disproportionate to their weight loss alone