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Optic neuritis as an early sign of multiple sclerosis

Aimelia Papakonstantinou started a new position as Associate Professor at the Agricultural University of Athens in Athens, Greece

63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidationreduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2 (eIF2) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)