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Uric Acid Uric Acid Normal Range - 0.21 - 0.42 mmol/L Aim of Urate lowering therapy is to bring uric acid levels to less than 0.3 mmol/L Risk Factors for Gout Factor which increase uric acid production are male sex, alcohol consumption, obesity, weight gain Factors which reduce renal clearance of uric acid are diuretics, low dose salicylates (aspirin), renal insufficiency

Hanno P and Dmochowski R: Status of international consensus on interstitial cystitis/bladder pain syndrome/painful bladder syndrome: 2008 snapshot

& Fiedor, J

21,22,23 Dosing considerations for switching between routes of administration When a patient is switched from one route of administration to another, finding the correct dosing can be a challenge