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This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm

Swelling and Tenderness: The heel may become swollen or bruised, and the area can be tender to the touch

The heterogeneity of participant recruitment criteria and the lack of control of variables that influence circulating BDNF levels regardless of dementia, such as depressive symptoms, medications, lifestyle, lack of overlap between serum and plasma, and experimental aspects are likely to bias results and prevent study comparability (Balietti et al., 2018)

Further REIMAGINE results presented at the ADA meeting in June 2026 reinforced that signal across diverse patient groups