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Description

P53 can inhibit cysteine uptake by downregulating SLC7A11, reducing GPX activity and GSH synthesis and subsequently causing intracellular ROS accumulation and ferroptosis (83)

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Neetu D, Ajay KS, Piush S

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Cell Mol Life Sci 58:760793 Li N, Wei Y, Li R, Meng Y, Zhao J, Bai Q, Wang G, Zhao Y (2025) Modulation of the human GlyT1 by clinical drugs and cholesterol

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