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Progesterone agents include oral or depot medroxyprogesterone acetate, oral 19-nortestosterone derivatives such as norethindrone acetate and norgestrel, and levonorgesterol-releasing intrauterine device

Other, more variable features include optic atrophy, congenital heart defects, short stature, and significant neurological deficits such as stroke and epilepsy during infancy (77, 86)

Each of these B Vitamins contribute to normal energy-yielding metabolism as well as the maintenance of normal function of the nervous system

This research is dedicated to the Late Sir Robert B Elliott, Former Professor of Paediatrics and Child Health Research, University of Auckland, Auckland, New Zealand