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To understand why senescent cells are more prone than normal counterparts to undergo ferroptosis on GPX4 inhibition, we used fluorescence probes to analyse ROS, levels of Fe 2+ and lipid oxidation in senescent cells

This work was supported by the Wilmot Cancer Institute Predoctoral Fellowship (G.A.), Wilmot Cancer Institute Pilot Funding (I.S.H.), the American Association for Cancer Research and Breast Cancer Research Foundation (20-20-26-HARR) (I.S.H.), Breast Cancer Coalition of Rochester (I.S.H.), a Sir Henry Wellcome Postdoctoral Fellowship (M.E.K.), and a FNR-CORE grant C21/BM/15796788 (D.B.), and NIH grants R01CA269813 (I.S.H.), R37CA230042 (G.M.D), R24AA022057 (V.V.), R01AA028859 (Y.C.), AI150698 (J.M.), K01CA240533-01A1 (C.L.C.), and R01AR078000 (R.T.D.)

Methylation reaction : DNA methylation: DNA methyltransferase (DNMT) uses SAM as donor to catalyze CpG island methylation (epigenetic silencing)

In recent years, glutathione has gained attention for its incredible skin benefits, particularly in the realms of anti-aging and skin brightening