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Furthermore, EV fractions stored at 80 C or snap-frozen in liquid nitrogen before storage at 80 C remained functional (Fig

The binding of HK2 to mitochondria increases the glycolytic capacity and promotes PDAC immortalization [28]

Meanwhile, there was also research found iron overload in HSCs can promote fibrogenic activation [64]

Finally, the metabolites generated by pyruvate entering the tricarboxylic acid (TCA) cycle, including -ketoglutaric acid (KG) (2224) and citrate (25, 26), significantly inhibit intracellular senescence