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found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

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They find that for the efficacy of l-carnitine on fasting plasma glucose (FPG), 2 g/day l-carnitine is required for at least 36.1 weeks