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The TRIUMPH-4 trial showed that retatrutide at 12mg reduced: Systolic blood pressure: 14.0 mmHg reduction Non-HDL cholesterol: clinically meaningful improvement High-sensitivity C-reactive protein: significant reduction (a marker of systemic inflammation) Triglycerides: substantial decrease Tirzepatide produces similar cardiovascular improvements, with well-documented reductions in blood pressure, triglycerides, and inflammatory markers across the SURMOUNT and SURPASS programs

Otte JM, Werner I, Brand S, Chromik AM, Schmitz F, Kleine M, Schmidt WE: Human -defensin 2 promotes intestinal wound healing in vitro

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