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Statins are potent inhibitors of HMGCR, which plays a crucial role in controlling cholesterol biosynthesis through the mevalonate pathway (MVA) (Yu et al., 2017)

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The copper- and zinc-containing cytosolic SOD (Cu/Zn SOD, SOD1) is a 32 kDa homodimer abundantly expressed in astrocytes and present in plasma, lymph, and cerebrospinal fluids [14]