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The most modulated genes found through the network approach were SIRT3, FOXO1, and PPARGC1A, these proteins were also found to have the highest docking results, several studies have reported the role of these proteins in the modulation of ROS and oxidative stress via mitochondria, as ROS and oxidative stress have been reported to alter various cellular signaling pathways and cause neuronal death

We found other findings from clinical observations in which two patients with PD received certain chemicals including magnesium, chromium, zinc, vitamin D, and tadalafil 5, the results of such an approach showed ameliorating effects of PD symptoms