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Previous work from our groups showed that GNMT expression is reduced in aged rats (19 months old) compared to young adult rats (3 months old) and that this loss of expression can be ameliorated with dietary restriction 37

doi: 10.1053/j.gastro.2008.12.051

In December 2014, they published a paper in Nature Medicine, showing that the triple agonists weight loss effects in mice exceeded those of the dual agonists