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Description

Interventions that limit myeloid cell activation in the TME or immune cell trafficking to the tumor tissue may limit immunotherapy when not given concomitantly with drivers of appropriate inflammation such as ICB or PRR agonists

Varley, K

Tavlo, M

To further dissect upstream regulatory signals, we performed integrative bioinformatics analysis of the GSE28424 dataset and identified LCN2, an iron-chelating oncoprotein implicated in ferroptosis resistance ( 2+ accumulation, ROS normalization, GSH restoration, and SLC7A11/GPX4 protein recovery