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Disclosures: Lily Dara: Intercept Pharmaceuticals: Consultant, Intercept Pharmaceuticals: Grant/Research Support, Paola Nicoletti: Nothing to Disclose, Chaudry Majeed: Nothing to Disclose, Andrew Dellinger: Nothing to Disclose, David Kleiner: Nothing to Disclose, Mahmoud Mohamed: Nothing to Disclose, Tatyana Kushner: Gilead: Grant/Research Support, Gilead: Advisor, GSK: Advisor, Eiger: Advisor, Mohammed Umair Masood: Nothing to Disclose, Raj Vuppulanch: Eli Lilly: Grant/Research Support, Echosens: Consultant, Zydus THerapeutics: Grant/Research Support, GSK: Consultant, MERCK: Advisor, Takeda: Grant/Research Support, Huiman Barnhart: Nothing to Disclose, Jiezhun Gu: Nothing to Disclose, Herbert Bonkovsky: Nothing to Disclose 1252 CO-ADMINISTRATION OF ALCOHOL, RITONAVIR AND LOPINAVIR AFFECTS EXPRESSION OF THE SET CHEPERONE PROTEIN IN HEPATOCYTES AND MONOCYTES AND HIV-1 INFECTIVITY IN VITRO Liting Chen 1 Marina Kaypaghian 1 Cheng Ji 1 , 1 University of Southern California Background: Combined use of alcohol and antiviral drugs is known to cause cellular stress and organ injury raising peoples vulnerability to virus infection