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Additionally, they downregulated Matrix Metalloproteinases (MMP2 and MMP9), key mediators of uterine matrix degradation, and suppressed p-STAT3 signaling while enhancing p-IRS1 and p-PI3K expression, indicating improved insulin signaling in the uterine tissues

Importantly, recent clinical trials using such personalized interventions demonstrated improved glycemic control and reduced HbA1c in both prediabetic and newly diagnosed T2D when compared to a Mediterranean diet intervention [120, 121]

10.1038/s41598-022-10607-z

This embodies the mechanism of "unblocking meridians and collaterals" to modulate zang-fu metabolic function