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Science 382 , eadd7046 (2023)

PINK1 targets dysfunctional mitochondria for autophagy in Parkinson disease

Ferroptosis inhibitors, such as ferrostatin-1 and deferoxamine, aim to reduce iron accumulation, prevent lipid peroxidation, and stabilize cellular integrity, offering therapeutic potential in critically ill patients ( 5.1 Therapeutic strategies targeting ferroptosis inhibitors and their potential in critical illnesses Any approach that inhibits ferroptosis works by targeting the specific mechanisms underlying this process, including iron chelation, inhibition of System Xc-, and blockade of lipid peroxidation pathways