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Asthma patients are susceptible to impaired respiratory mucosal immunity, and e-cigarettes further damage the immune function of the respiratory mucosa, including the functions of epithelial cells, macrophages, and neutrophils, affecting the development, severity, and acute exacerbations of asthma [71]

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Philip Morris turned to the Chicago-based Leo Burnett agency, whose advertisers dropped Marlboro's price point and long-time "Mild as May" slogan, and staged a new campaign featuring icons of male autonomy: sun-cured men repairing cars, cleaning guns, cupping a flame in tattooed hands, or squinting into the distance over whirls of smoke

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