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Although PYC has been shown to reduce CRP levels, existing trials are limited by small sample sizes (e.g., five studies totaling approximately 324 participants in a CRP meta-analysis), high heterogeneity (I 2 99%), and variability in dosing regimens, treatment duration, and study populations ( Similarly, although PYCs anticancer effects have been demonstrated in multiple cell lines and preclinical models, translational data remain limited

The cysteine residue in the molecule center is liable for the high reduction potential of GSH

In this review, we depict the lung susceptibility and the molecular profiles of tumors with the potential for lung metastasis