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These findings provide primary evidence for the exhaustion of CD4 + T cells by defining the inhibitory phenotype and the changes of CD4 + T-cell function during chronic HBV infection, and provide new insights into the mechanisms underlying CD4 + T-cell exhaustion, as well as novel immunological approaches for prospective therapeutic strategy for persisting HBV infection

If your mitochondria are the power plants that burn fat, "flux" is the speed and efficiency with which fuel enters the plant, gets processed, and exits as pure, usable energy