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Zinc plays a vital role in maintaining the homeostasis of intestinal epithelial cells, and its deficiency can lead to alterations in their integrity and function

Regularly, astrocytes are the main source of NO, however, it has been shown that NT2 neurons can produce NO and therefore increase levels of cGMP (Denninger and Marletta, 1999)

Cadmium (Cd) is a common heavy metal contaminant that has been demonstrated to cause organ damage through the activation of inflammatory processes, oxidative stress, mitochondrial damage, and cell death, which ultimately leads to neurotoxicity, gastrointestinal damage, renal damage, and reproductive damage [124, 125]