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At the protein level, R2 expression was more sensitive than expression of R1 to down-regulation upon p53 stabilization (Fig 3D)

Methods Strains and culturing conditions A

Given the exhaustion of GSH is a pivotal mechanism in ferroptosis, these findings support the notion that ferroptosis may be a key pathological process in intrinsic DILI

4-chloro-3-hydroxybutyronitrile is synthesized from epichlorohydrin in an aqueous hydrogen cyanide solution 4-chloro-3-hydroxy butyric acid alkyl ester is then synthesized from the 4-chloro-3-hydroxybutyronitrile in the presence of an alcohol and a sulfuric acid catalyst the racemic 4-chloro-3 -hydroxy butyric acid alkyl ester is hydrolyzed in an aqueous solution using an enzyme, thereby preparing (R)-4-chloro-3-hydroxy butyric acid alkyl ester