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Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys

ERAD safeguards pancreatic -cell identity and insulin secretion Pancreatic -cells are uniquely vulnerable to ER stress due to their high insulin biosynthetic demand

Finally, a number of factors independent of epidemiological evidence point toward a causal role of early exposure to APAP in the induction of neurodevelopmental disorders, particularly ASD [2,3]

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