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For instance, HIF-1 is a key regulator and plays a key role through signal transduction in the process of cancer angiogenesis, metabolism, invasion, and metastasis [25, 39]

Karabova MK, Cowley SA, James WS

doi: 10.1016/j.mito.2013.01.008 15

When ROS were initially integrated into biomedical concepts it was thought that they caused exclusively toxic effects and were associated with pathologies