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10.1186/1476-4598-12-86 31 ImaiS.ArmstrongC

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These markers were identified as adverse prognostic factors using immunohistochemical staining of diagnostic biopsy tissue.[14][Level of evidence C2] Presence of NF1 appears to be associated with an unfavorable prognosis, but the data are mixed.[4,15] For patients with localized disease in the MD Anderson Cancer Center study, there was no significant difference in outcome between patients with and without NF1.[9] In other studies, it was not clear whether the absence of NF1 was a favorable prognostic factor as it has been associated with both favorable [8] and unfavorable outcomes.[1,8,10] In the French Sarcoma Group study, NF1 was associated with other adverse prognostic features, but was not an independent predictor of poor outcome.[12] A retrospective analysis of cancer registry data from the Netherlands identified 784 patients with MPNST