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CLSM images (Figure 7) revealed that 8-MOP encapsulated in dendrimers was able to penetrate into deep skin layers, epidermis and dermis, compared to standard formulation

Positive controls, including T3 (3,3,5-Triiodo- L-thyronine sodium salt, Sigma, T6397) at 30 nM and clemastine fumarate (Sigma, SML0445) at 500 nM were used as positive controls, with their respective vehicles (DMSO and PBS) as negative controls

The vibrant blue color is a visual marker of active copper content and proper formulation

If stacking cagrilintide with a GLP-1 agonist, stagger injection times by at least 6-8 hours to avoid compounding gastric side effects