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Decreased expression of survivin contributes to the sensitization of cancer cells to chemotherapy by IGF-IR inhibitors

This is why the titration schedule exists

10.1016/j.freeradbiomed.2019.07.001 [DOI] [PMC free article] [PubMed] [Google Scholar] Hullin R., Metrich M., Sarre A., Basquin D., Maillard M., Regamey J., et al