beneficios de la l-carnitina L-Carnitina: qué es, para qué sirve y Beneficios de la L-Carnitina |

doi: 10.1530/JOE-14-0283 152 ExleyMAHandLEOSheaDLynchL

Prolonged, untreated autonomic dysfunction may ultimately lead to heart failure

Spermidine/spermine N1-acetyltransferase 1 (SSAT) initiates polyamine catabolism, which decreases the cellular content of polyamines through transferring the acetyl group of acetyl-CoA to either spermidine or spermine, which can be oxidized by peroxisomal enzyme polyamine oxidase (PAOX)

The pathological engagement of ferroptosis has been demonstrated in both patients with IBD and experimental models, including elevated iron deposition, glutathione (GSH) exhaustion, GPX4 inactivation and lipid peroxidation, which together contribute to intestinal cell death and sustained inflammation (5,11,12,15)