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Heise T, DeVries JH, Urva S, Li J, Pratt EJ, Thomas MK, Mather KJ, Karanikas CA, Dunn J, Haupt A, Milicevic Z, Coskun T

Acute hepatitis due to kava kava and St Johns Wort: an immune-mediated mechanism

After exposure to oxidative and/or electrophilic stimuli, Nrf2 is released from structurally modified Keap1 and translocates into the nucleus, forms a heterodimer with one of the small musculoaponeurotic fibrosarcoma (Maf) proteins, and activates the ARE-mediated expression of cytoprotective genes

For example, when cancer cells develop resistance to apoptosis (e.g., due to high expression of BCL-2 protein or Caspase inactivation), inducing ferroptosis can serve as an effective alternative strategy to eliminate these cells