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By reducing the expression of the androgen-responsive gene Fkbp5 and blocking PHLPP-mediated AKT inhibition, conditional AR deletion in the epithelium increases the proliferation of PTEN null cancer cells

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JC-1 exists in two forms: in healthy, non-apoptotic cells with intact mitochondrial membrane potential, it accumulates in the mitochondria as red-fluorescent aggregates, whereas in apoptotic or depolarized cells it remains in its monomeric green-fluorescent form