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Tobacco is an annual crop, which is usually harvested mechanically or by hand

A research study has revealed that high levels of nicotine concentrations found in Juul e-cigarettes are: Sufficiently high to be cytotoxic, or toxic to living cells when test in vitro with cultured respiratory system cells. Of the hundreds of electronic cigarette products analyzed by the research team, Juul was the only product with high enough nicotine concentrations to be toxic in standard cytotoxicity tests

It went on to add the caveat that those figures only include the ones that the agency knows about and may not cover every one that happened in that time

You Will Be Certain of What You Are Smoking