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Gefitinib inhibited the downregulation of ER by EGFR and restored the sensitivity of cells to tamoxifen to a certain extent (Jeong et al., 2019)

Myofibroblasts, the key effector cells in fibrosis, arise from fibroblasts, pericytes, endothelial cells, or epithelial cells via epithelialmesenchymal transition (EMT) under stimulation by transforming growth factor (TGF) -, clotting factors, and mechanical stress [11, 29, 34, 36]

Side Effects of NAC NAC is generally well tolerated, but some people experience mild side effects, particularly at higher doses: Nausea or stomach discomfort (the most common complaint, usually resolves after a few days or by taking with food) Diarrhoea at higher doses A sulphurous smell or taste (NAC is a sulphur-containing compound) Rarely, headache or skin rash NAC can interact with certain medications, particularly nitroglycerin (used for angina), where it may enhance the blood-pressure-lowering effect

The copper component is not merely a passive constituent but actively contributes to the biological effect