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The list of differentially expressed genes was uploaded to Ingenuity Pathway Analysis (QIAGEN IPA), and core analysis yielded a list of canonical pathways, of which the top 10 upregulated and downregulated pathways were visualized on bar plots using ggplot v3.5.0 [29]

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De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Rocken M, Lutjohann D, Wright SD, Schultze JL, Latz E