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M1 macrophages primarily rely on glycolysis for energy, exhibit increased mitochondrial ROS production and succinate accumulation, promoting Hypoxia-Inducible Factor-1 (HIF-1) stabilization and inflammatory gene expression

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Even though antidepressants such as trazodone do not produce a euphoric high, people continue to abuse the medication due to its sedating effects

Effects of a 6-month multifaceted diet and exercise intervention on cognition in older adults at risk of cognitive decline: the PONDER double-blind, placebo-controlled randomized trial