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HFD BE 200 mg kg -1 d -1 , OG TP: 12 wk #LW, #liver fat density #TC, TG, and glycogen levels #MDA and carbonyl protein levels "p-IRS-1, pAKT, PI3-1K, SLC2A2, pLKB1, pACACA, HMGCR, and pAMPK/AMPK ratio, ABCG5 and ABCG8, # SREBP-1c,"CAT, GPx, and SOD enzymatic activity #BW #Epididymal and retroperito- neal fat mass #Glu and Ins, HOMA-IR (serum) Charradi et al, 2014 51 Vitis vinifera etha- nolic extract M: Male Wistar rats A/W: 210-230 g 1

This profile not only involves high levels of PAI-1 and STAT3 as previously described, but also includes low levels of glutamine and NAD + , coupled with overproduction of hyaluronan (HA)

We will continue his protocol of TPE with 5% albumin replacement, UCT-MSC-EXs, Epitalon, and Semax indefinitely

doi: 10.1186/s12967-018-1514-7 32 SeidelJAOtsukaAKabashimaK