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At 12 min past IV injection, almost all of the AOD9604 had cleared from the blood plasma, resulting in a relatively small AUC

DDD is thought to be due to chronic activation of the alternative complement pathway

Pidugu LS, Flowers JW, Coey CT, Pozharski E, Greenberg MM, Drohat AC

In the CNS, glutamate is present in more than one type of cell and distributed in many subcellular compartments, including the cytoplasm and mitochondria (Nedergaard et al., 2002)