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This integrated workflow connects gene-level regulation with metabolic outputs, helping researchers move from descriptive data to testable hypotheses and actionable biomarkers

26 It leads to the deregulation of gene expression and consequently to impairment of cellular physiological aging, cessation of cell growth, and eventually cell death

No human PK or clinical data exists

In a 12-week randomized controlled trial (RCT) involving 90 patients with HD, deutetrabenazine treatment resulted in a reduction of 4.4 units from the baseline in the UHDRS, the total maximal chorea score, compared with a reduction of 1.9 units on placebo treatment (treatment difference -2.5, 95% CI -3.7 to -1.3