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Beneficial commensals generally promote immune tolerance and help reinforce the intestinal barrier, whereas an overgrowth of pathogenic bacteria or loss of key symbionts (dysbiosis) can provoke systemic inflammation [34]

Misonidazole GPX can combine to an electrophilic compound that might result in loss of its activity

Biochim Biophys Acta BBAGen Subj 1830(5):32893303 Valko M, Jomova K, Rhodes CJ, Kua K, Muslek K (2016) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

Ongoing clinical trials are actively unveiling insights into the prospective applications of IPN60090 in cancer therapy, shedding light on its potential therapeutic significance (NCT03894540, NCT05039801)