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Uptake of extracellular asparagine prevents the death of glioblastoma cells in response to glutamine depletion by blocking the apoptotic function of a glutamine-induced endoplasmic reticulum stress marker protein, ATF4, and by increasing glutamate-ammonia ligase (GLUL)-mediated glutamine and protein synthesis 116,117

The transformation of cobalamin to intracellular MeCbl in the cytosol requires a methyl donor from the reaction of tetrahydrofolate to 5-methyltetrahydrofolate and is affected by methionine synthase

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