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Lower tCho at 3 months was significantly associated with higher somatic symptoms at 3 months (B = 5.02, p = 0.003, r = 0.216, Fig

RAS overactivation elevates reactive oxygen species (ROS), damaging the vascular endothelium and neurons and linking ASCVD and HF to neuroinflammatory disorders such as depression

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Collectively, the evidence supports a model wherein magnesium deficiency, often a sequel of advanced liver disease, acts as a disease-modifying amplifier within the established carcinogenic cascade of HCCworsening genomic integrity and weakening immune controlrather than serving as a primary driver