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LL-37 can be degraded by bacterial and host proteases, has demonstrated toxicity to host cells at high concentrations, and is costly to synthesize at scale

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In contrast, iron supplementation had no significant impact on lesion progression in this model, likely due to the intrinsic resistance of EMS lesions to iron overload-induced ferroptosis

Various authors have demonstrated differences in the mitochondrial transcriptome and proteome across different populations of neuronal cells (Wynne et al., 2021)