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doi: 10.1016/j.aquaculture.2024.740637 5 PurisEKouilNajdekrLAuriolaSLoppiSKorhonenPet al

In patients affected by a cytokine storm and treated with anti-IL-6 and/or anti-IL1 agents such as tocilizumab, siltuximab and canakinumab, an upregulation of CYP3A4 activity may be expected [57]