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These models allow for transmigration studies as well as more precise measurements of TEER making them very useful in permeability studies and reduces the number of cells needed for the model [117]

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It does not automatically establish sterility, authorisation, safety or suitability for human or veterinary administration

The dual-mechanism approach may also offer specific advantages for particular patient subgroups, including those with type 2 diabetes and obesity where cardiometabolic improvements beyond weight loss are clinically important