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In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations

Taurine is particularly important for marine and brackish water fish, which are often exposed to fluctuating salinity levels [35]

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